1,4-二巯基苏糖醇对溶菌酶淀粉样纤维化的抑制作用

蛋白质淀粉样纤维化是很多人类疾病的重要特征,筛选蛋白质淀粉样纤维化的抑制剂对于研究和开发相关疾病的治疗药物具有重要意义。本文采用溶菌酶作为模型,探索巯基化合物1,4-二巯基苏糖醇(DTT)对蛋白质淀粉样纤维化的抑制作用。结果表明,DTT对溶菌酶淀粉样纤维化具有较强的抑制作用,其IC50数值为17μmol.L-1。DTT抑制溶菌酶纤维化的作用与其巯基结构有关。在溶菌酶分子高级结构改变产生聚集和纤维化的过程中,DTT分子的巯基通过与溶菌酶的二硫键作用改变了多肽的构象,从而改变了溶菌酶纤维化的进程。     

锥形剖面径向复合超声换能器的机电等效电路

研究了一种锥形剖面径向复合超声换能器。该换能器由一个等截面内金属圆环、一个轴向极化的压电陶瓷圆环和一个锥形剖面外金属圆环沿径向复合而成,且换能器的径向尺寸远大于高度。锥形剖面外金属圆环满足关系式h=h₀r,h₀为厚度变化常数。基于平面应力径向振动理论,推导了换能器的机电等效电路,得到了共振频率方程和反共振频率方程,进而研究了换能器的振动特性。并将理论计算的第1阶、第2阶径向共振频率和反共振频率与数值仿真结果相比较,二者结果一致。研究表明:锥形剖面换能器第1阶、第2阶径向共振频率、反共振频率、有效机电耦合系数不仅与换能器各部分的材料、径向几何尺寸有关,还与h₀有关。h₀越大,第1阶径向共振频率、反共振频率越大,有效机电耦合系数先增大后减小。与等截面相比,锥形剖面换能器沿径向向外辐射声波,辐射面积更大,辐射声功率更高,指向性更好。      

How Does van der Waals Confinement Enhance Phonon Transport?

We study the mechanism of van der Waals(vdW)interactions on phonon transport in atomic scale,which would boost developments in heat management and energy conversion.Commonly,the vdW interactions are regarded as a hindrance in phonon transport.Here we propose that the vdW confinement can enhance phonon transport.Through molecular dynamics simulations,it is realized that the vdW confinement is able to make more than two-fold enhancement on thermal conductivity of both polyethylene single chain and graphene nanoribbon.The quantitative analyses of morphology,local vdW potential energy and dynamical properties are carried out to reveal the underlying physical mechanism.It is found that the confined vdW potential barriers reduce the atomic thermal displacement magnitudes,leading to less phonon scattering and facilitating thermal transport.Our study offers a new strategy to modulate the phonon transport.     

Some Measurement-Based Characterizations of Separability of Bipartite States

Importance of quantum entanglement has been demonstrated in various applications. Usually, separability of a bipartite state is defined by its algebraic structure, i.e. a convex combination of product states. But it seems to be hard to check separability (equivalently, entanglement) of a state from its algebraic structure. In this note, we give some characterizations of separability of bipartite states based on POVM measurements. For bipartite pure states, we prove the separability, Bell locality, unsteerability and classical correlation are the same. As a consequence, every entangled pure bipartite state is always Bell nonlocal, steerable and quantum correlated.

     

Two Families of Entanglement-Assisted Quantum MDS Codes from Cyclic Codes

International Journal of Theoretical Physics - With entanglement-assisted (EA) formalism, arbitrary classical linear codes are allowed to transform into EAQECCs by using pre-shared entanglement...     

Interaction between lactose and cadmium chloride in aqueous solutions as seen by diffusion coefficients measurements

Diffusion coefficients of an aqueous system containing cadmium chloride 0.100 mol · dm⁻³ and lactose at different concentrations at 25 °C have been measured, using a conductimetric cell and an automatic apparatus to follow diffusion. The cell relies on an open-ended capillary method and a conductimetric technique is used to follow the diffusion process by measuring the resistance of a solution inside the capillaries, at recorded times. From these results and by ab initio calculations, it was possible to obtain a better understanding of the effect of lactose on transport of cadmium chloride in aqueous solutions.     

Estimation of biophysical properties of cell exposed to electric field

Excitable media,such as cells,can be polarized and magnetized in the presence of an external electromagnetic field.In fact,distinct geometric deformation can be induced by the external electromagnetic field,and also the capacitance of the membrane of cell can be changed to pump the field energy.Furthermore,the distribution of ion concentration inside and outside the cell can also be greatly adjusted.Based on the theory of bio-electromagnetism,the distribution of field energy and intracellular and extracellular ion concentrations in a single shell cell can be estimated in the case with or without external electric field.Also,the dependence of shape of cell on the applied electronic field is calculated.From the viewpoint of physics,the involvement of external electric field will change the gradient distribution of field energy blocked by the membrane.And the intracellular and extracellular ion concentration show a certain difference in generating timevarying membrane potential in the presence of electric field.When a constant electric field is applied to the cell,distinct geometric deformation is induced,and the cell triggers a transition from prolate to spherical and then to oblate ellipsoid shape.It is found that the critical frequency in the applied electric field for triggering the distinct transition from prolate to oblate ellipsoid shape obtains smaller value when larger dielectric constant of the cell membrane and intracellular medium,and smaller conductivity for the intracellular medium are used.Furthermore,the effect of cell deformation is estimated by analyzing the capacitance per unit area,the density of field energy,and the change of ion concentration on one side of cell membrane.The intensity of external applied electric field is further increased to detect the change of ion concentration.And the biophysical effect in the cell is discussed.So the deformation effect of cells in electric field should be considered when regulating and preventing harm to normal neural activities occurs in a nervous system.     

Magnetic-resonance image segmentation based on improved variable weight multi-resolution Markov random field in undecimated complex wavelet domain

To solve the problem that the magnetic resonance (MR) image has weak boundaries, large amount of information, and low signal-to-noise ratio, we propose an image segmentation method based on the multi-resolution Markov random field (MRMRF) model. The algorithm uses undecimated dual-tree complex wavelet transformation to transform the image into multiple scales. The transformed low-frequency scale histogram is used to improve the initial clustering center of the K-means algorithm, and then other cluster centers are selected according to the maximum distance rule to obtain the coarse-scale segmentation. The results are then segmented by the improved MRMRF model. In order to solve the problem of fuzzy edge segmentation caused by the gray level inhomogeneity of MR image segmentation under the MRMRF model, it is proposed to introduce variable weight parameters in the segmentation process of each scale. Furthermore, the final segmentation results are optimized. We name this algorithm the variable-weight multi-resolution Markov random field (VWMRMRF). The simulation and clinical MR image segmentation verification show that the VWMRMRF algorithm has high segmentation accuracy and robustness, and can accurately and stably achieve low signal-to-noise ratio, weak boundary MR image segmentation.